Liver inflammation: Mono can cause liver inflammation, leading to jaundice (yellow-colored skin), abdominal pain, and fluid buildup in the abdomen.A ruptured spleen requires immediate medical attention. Ruptured spleen: Some people with mono will experience a swollen spleen in some cases, it can rupture (burst) and cause severe abdominal pain.For a very swollen throat interfering with swallowing, your doctor may offer a steroid, such as prednisone.
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